David’s drawing of our hypothesis of a situation where CRAC-GFP is present only at the leading edge of a cell. See his blog post, “Think globally, act locally.” Edit: Actually, there are two hypotheses! Local activation, global inhibition is one; The other is the attachment of a reader (PH domain)-marker (GFP)-writer (PI3K) complex. That one was mine.

David’s drawing of our hypothesis of a situation where CRAC-GFP is present only at the leading edge of a cell. See his blog post, “Think globally, act locally.”

Edit: Actually, there are two hypotheses! Local activation, global inhibition is one; The other is the attachment of a reader (PH domain)-marker (GFP)-writer (PI3K) complex. That one was mine.